LRSAM1 Polyclonal Antibody

Overview
Catalog #	bs-9387R
Product Name	LRSAM1 Polyclonal Antibody
Applications	WB IHC-P IF(IHC-P)
Reactivity	Mouse
Predicted Reactivity	Human, Rat, Cow, Sheep, Horse
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human LRSAM1
Immunogen Range	201-300/723
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	90678
Synonyms	E3 ubiquitin protein ligase LRSAM1; hTAL; Leucine rich repeat and sterile alpha mot containing protein 1; RLE; TAL; Tsg101 associated ligase; LRSM1_HUMAN.
Background	LRSAM1 is an E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivation of the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. It selectively regulates cell adhesion molecules and plays a role in receptor endocytosis and viral budding. LRSAM1 contains a RING-type zinc finger, 5 leucine-rich repeats and 1 SAM (sterile alpha motif) domain. The coiled coil domains interact with the SB domain of TSG101. The PTAP motifs mediate the binding to UEV domains. There are 3 isoforms produced by alternative splicing.
Application Dilution
WB	1:300-5000
IHC-P	1:200-400
IF(IHC-P)	1:50-200