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    Presenilin 1 Polyclonal Antibody, Biotin Conjugated

    Catalog # bs-0024R-Biotin
    Product Name Presenilin 1 Polyclonal Antibody, Biotin Conjugated
    Applications WB, IHC-P
    Reactivity Human, Mouse, Rat
    Conjugation Biotin
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from mouse Presenilin-1 NTF subunit
    Immunogen Range 1-50/467
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Gene ID 5663
    Swiss Prot P49768
    Subcellular location Cytoplasm
    Synonyms AD3; FAD; PS1; PS-1; S182; Presenilin-1; Protein S182; PSEN1; PSNL1
    Background Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.