presenilin 1 Polyclonal Antibody, Cy5.5 Conjugated

Applications

  • IF(IHC-P)

Reactivity

  • Human
  • Rat
  • Rabbit
Overview
Catalog # bs-0025M-Cy5.5
Product Name presenilin 1 Polyclonal Antibody, Cy5.5 Conjugated
Applications IF(IHC-P)
Reactivity Human, Rat, Rabbit
Specifications
Conjugation Cy5.5
Host Mouse
Source KLH conjugated synthetic peptide derived from human Presenilin-1 CTF subunit
Immunogen Range 250-300/467
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Target
Gene ID 19164
Swiss Prot P49769
Subcellular location Cytoplasm
Synonyms PS1; Ad3h; PS-1; S182; Presenilin-1; Protein S182; Psen1; Psnl1
Background Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
Application Dilution
IF(IHC-P) 1:50-200