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    PP2A alpha / beta Polyclonal Antibody

    Description:
    Applications:
    • WB
    • IHC-P
    • IF(IHC-P)
    Overview
    Catalog # bs-0029R
    Product Name PP2A alpha / beta Polyclonal Antibody
    Applications WB, IHC-P, IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation Unconjugated
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human PP-2A
    Immunogen Range 267-309/309
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Target
    Gene ID 5515
    Swiss Prot P67775
    Subcellular location Cytoplasm, Nucleus
    Synonyms RP-C; PP2Ac; PP2CA; PP2Calpha; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; PPP2CA
    Background PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV4 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
    Applications
    Application Dilution
    WB 1:100-1000
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200