Caspase-10 Polyclonal Antibody, Biotin Conjugated

Applications

  • IHC-P
  • IHC-F

Reactivity

  • Human
Overview
Catalog # bs-0092R-Biotin
Product Name Caspase-10 Polyclonal Antibody, Biotin Conjugated
Applications IHC-P, IHC-F
Reactivity Human
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human Caspase-10
Immunogen Range 431-521/521
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 843
Swiss Prot Q92851
Subcellular location Cytoplasm
Synonyms MCH4; ALPS2; FLICE2; Caspase-10; CASP-10; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; ICE-like apoptotic protease 4; CASP10
Background Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform C is proteolytically inactive.
Application Dilution
IHC-P 1:100-500
IHC-F 1:100-500