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    M2-PK Polyclonal Antibody

    Description:
    Applications:
    • WB
    • IHC-P
    • IF(IHC-P)
    Overview
    Catalog # bs-0102M
    Product Name M2-PK Polyclonal Antibody
    Applications WB, IHC-P, IF(IHC-P)
    Reactivity Human, Rat
    Specifications
    Conjugation Unconjugated
    Host Mouse
    Source KLH conjugated synthetic peptide derived from human M2-PK
    Immunogen Range 70-120/531
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Target
    Gene ID 5315
    Swiss Prot P14618
    Subcellular location Cytoplasm, Nucleus
    Synonyms PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30; Pyruvate kinase PKM; Cytosolic thyroid hormone-binding protein; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Tumor M2-PK; p58; PKM; PK2
    Background Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
    Applications
    Application Dilution
    WB 1:300-1000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200