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    GTP cyclohydrolase 1 Polyclonal Antibody, Biotin Conjugated

    Catalog # bs-0136R-Biotin
    Product Name GTP cyclohydrolase 1 Polyclonal Antibody, Biotin Conjugated
    Applications WB, IHC-P
    Reactivity Human, Mouse, Rat
    Conjugation Biotin
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human GTP-CH-1
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Gene ID 2643
    Synonyms GTP-CH-1; DYT 5; DYT5; GCH 1; GCH; GCH1; GTP CH 1; GTP CH I; GTP cyclohydrolase 1 dopa responsive dystonia; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTPCH 1; GTPCH1; Guanosine 5' triphosphate cyclohydrolase I.
    Background GTP cyclohydrolase I (also designated dopa-responsive dystonia) catalyzes the conversion of GTP to D-erythro-7,8-dihydroneopterin triphosphate, the first and rate-limiting step in tetrahydrobiopterin (BH4) biosynthesis. Tetrahydrobiopterin is an essential cofactor for 3 aromatic amino acid monooxygenases: phenylalanine, tyrosine, and tryptophan hydroxylases. Animals can synthesize tetrahydrobiopterin in vivo from GTP through several enzymatic reactions.