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    HCV-NS4a Polyclonal Antibody

    Description:
    Applications:
    • IHC-P
    • IF(IHC-P)
    Overview
    Catalog # bs-0213R
    Product Name HCV-NS4a Polyclonal Antibody
    Applications IHC-P, IF(IHC-P)
    Reactivity Virus
    Specifications
    Conjugation Unconjugated
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from HCV-NS4a
    Immunogen Range 1694-1735/3010
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Target
    Synonyms HCV-NS4a; Non-structural protein 4A; NS4A;POLG_HCVBK.
    Background Hepatitis C virus (HCV) is an enveloped, positive-strand RNA virus classified within the genus Hepacivirus in the family Flaviviridae. The nonsegmented HCV genome is 9.6-kb and encodes a long polyprotein that is cleaved by cellular and viral proteases into at least 10 distinct products. The N-terminal region of this polyprotein encodes the viral structural proteins: core and two envelope glycoproteins, E1 and E2. The remainder of the polyprotein encodes nonstructural (NS) proteins: p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B. NS4A is the smallest NS protein. It encodes an N-terminal hydrophobic alpha-helix that anchors NS3-4A to cellular membranes, a middle “cofactor” peptide that forms a beta-strand and contributes to proper folding of the NS3 serine protease domain, and a C-terminal acidic region that forms an alpha-helix at low pH.
    Applications
    Application Dilution
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200