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    PBEF (CT) Polyclonal Antibody, HRP Conjugated

    Overview
    Catalog # bs-0273R-HRP
    Product Name PBEF (CT) Polyclonal Antibody, HRP Conjugated
    Applications IHC-P
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation HRP
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Nicotinamide phosphoribosyltransferase
    Immunogen Range 400-450/491
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
    Target
    Gene ID 10135
    Swiss Prot P43490
    Subcellular location Cytoplasm, Nucleus, Secreted
    Synonyms VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor
    Background Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).