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    C5a anaphylatoxin Polyclonal Antibody

    Description:
    Applications:
    • IHC-P
    • IF(IHC-P)
    Overview
    Catalog # bs-0324R
    Product Name C5a anaphylatoxin Polyclonal Antibody
    Applications IHC-P, IF(IHC-P)
    Reactivity Mouse
    Specifications
    Conjugation Unconjugated
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from mouse C5a (725-770aa)
    Immunogen Range 700-755/1680
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Target
    Gene ID 15139
    Swiss Prot P06684
    Subcellular location Secreted
    Synonyms C5; He; C5a; Complement C5; Hemolytic complement; Hc
    Background Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
    Applications
    Application Dilution
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200