C5a anaphylatoxin Polyclonal Antibody, HRP Conjugated

Applications

  • WB
  • ELISA
  • IHC-P

Reactivity

  • Human
  • Mouse

Predicted Reactivity

  • Rat
Overview
Catalog # bs-0324R-HRP
Product Name C5a anaphylatoxin Polyclonal Antibody, HRP Conjugated
Applications WB, ELISA, IHC-P
Reactivity Human, Mouse
Predicted Reactivity Rat
Specifications
Conjugation HRP
Host Rabbit
Source KLH conjugated synthetic peptide derived from mouse C5a (725-770aa)
Immunogen Range 701-755/1680
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
Storage Condition Store at 4°C for 12 months.
Target
Gene ID 15139
Swiss Prot P06684
Subcellular location Secreted
Synonyms C5; He; C5a; Complement C5; Hemolytic complement; Hc
Background Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Application Dilution
WB 1:300-1000
ELISA 1:500-1000
IHC-P 1:200-400