Histone H3 Polyclonal Antibody, Cy3 Conjugated

Applications

  • FCM
  • IF(IHC-P)

Reactivity

  • Human
  • Mouse
  • Rat
  • Pig
Overview
Catalog # bs-0349R-Cy3
Product Name Histone H3 Polyclonal Antibody, Cy3 Conjugated
Applications FCM, IF(IHC-P)
Reactivity Human, Mouse, Rat, Pig
Specifications
Conjugation Cy3
Host Rabbit
Source KLH conjugated synthetic peptide derived from human Histone H3
Immunogen Range 90-136/136
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Target
Gene ID 3020
Swiss Prot P84243
Subcellular location Nucleus
Synonyms H3F3; H3.3A; Histone H3.3; H3F3A; PP781
Background Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Application Dilution
FCM 1:20-100
IF(IHC-P) 1:50-200