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    Histone H3 Polyclonal Antibody, Cy3 Conjugated

    Overview
    Catalog # bs-0349R-Cy3
    Product Name Histone H3 Polyclonal Antibody, Cy3 Conjugated
    Applications FCM, IF(IHC-P)
    Reactivity Human, Mouse, Rat, Pig
    Specifications
    Conjugation Cy3
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human Histone H3
    Immunogen Range 90-136/136
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 3020
    Swiss Prot P84243
    Subcellular location Nucleus
    Synonyms H3F3; H3.3A; Histone H3.3; H3F3A; PP781
    Background Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.