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    SOX2 Polyclonal Antibody

    Description:
    Applications:
    • WB
    • FCM
    • IHC-P
    • IF(IHC-P)
    • IF(ICC)
    Overview
    Catalog # bs-0523R
    Product Name SOX2 Polyclonal Antibody
    Applications WB, FCM, IHC-P, IF(IHC-P), IF(ICC)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation Unconjugated
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from mouse Transcription factor SOX-2
    Immunogen Range 230-280/319
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Target
    Gene ID 20674
    Swiss Prot P48432
    Subcellular location Nucleus
    Synonyms lcc; ysb; Sox-2; Transcription factor SOX-2; Sox2
    Background Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP26. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
    Applications
    Application Dilution
    WB 1:100-1000
    FCM 1:20-100
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200