Overview |
bs-0677R-HRP |
Angiopoietin 2 Polyclonal Antibody, HRP Conjugated |
WB, ELISA, IHC-P, IHC-F |
Human |
Mouse, Rat, Dog, Pig, Chicken |
Specifications |
HRP |
Rabbit |
KLH conjugated synthetic peptide derived from human Angiopoietin 2 |
401-496/496 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
285 |
O15123 |
Secreted |
ANG2; AGPT2; Angiopoietin-2; ANG-2; ANGPT2 |
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
Application Dilution |
WB |
1:300-5000 |
ELISA |
1:500-1000 |
IHC-P |
1:200-400 |
IHC-F |
1:100-500 |