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    CDKN1A Polyclonal Antibody, Cy5.5 Conjugated

    Overview
    Catalog # bs-0741R-Cy5.5
    Product Name CDKN1A Polyclonal Antibody, Cy5.5 Conjugated
    Applications IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation Cy5.5
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from mouse P21
    Immunogen Range 120-155/159
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
    Target
    Gene ID 12575
    Swiss Prot P39689
    Subcellular location Cytoplasm, Nucleus
    Synonyms P21; CDKI; CIP1; SDI1; Waf1; mda6; CAP2; Cdkn1; p21WAF; p21Cip1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein; Cdkn1a
    Background May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).