KISS1 Polyclonal Antibody, Biotin Conjugated

Applications

  • WB
  • IHC-P
  • IHC-F

Reactivity

  • Human
  • Mouse
  • Rat

Predicted Reactivity

  • Cow
  • Sheep
Overview
Catalog # bs-0749R-Biotin
Product Name KISS1 Polyclonal Antibody, Biotin Conjugated
Applications WB, IHC-P, IHC-F
Specificity This antibody detects Kisspeptin-10 region of Kisspeptin.
Reactivity Human, Mouse, Rat
Predicted Reactivity Cow, Sheep
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human KISS1
Immunogen Range 81-145/145
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 3814
Swiss Prot Q15726
Subcellular location Secreted
Synonyms HH13; KiSS-1; Metastasis-suppressor KiSS-1; Kisspeptin-1; KISS1; PP598
Background Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-1 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-1, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-1 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
Application Dilution
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500