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    AKT1/2/3 (Ser472/Ser473/Ser474) Antibody

    Description:
    Applications:
    • WB
    • IHC-P
    • IF(IHC-P)
    Overview
    Catalog # bs-0876R
    Product Name AKT1/2/3 (Ser472/Ser473/Ser474) Antibody
    Applications WB, IHC-P, IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation Unconjugated
    Host Rabbit
    Source KLH conjugated synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of Ser473
    Immunogen Range 450-480/480
    Modification Site Ser473
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Target
    Gene ID 24185
    Swiss Prot P47196
    Subcellular location Cytoplasm, Nucleus
    Synonyms Akt; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; RAC-PK-alpha; Akt1
    Background AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
    Applications
    Application Dilution
    WB 1:100-1000
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200