PDX1 Polyclonal Antibody

Applications

  • WB
  • IHC-P
  • IF(ICC)

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-0923R
Product Name PDX1 Polyclonal Antibody
Applications WB, IHC-P, IF(ICC)
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic peptide derived from mouse PDX1
Immunogen Range 190-222/284
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Target
Gene ID 18609
Swiss Prot P52946
Subcellular location Cytoplasm, Nucleus
Synonyms Ipf1; IDX-1; IPF-1; Mody4; STF-1; pdx-1; Pancreas/duodenum homeobox protein 1; Insulin promoter factor 1; Islet/duodenum homeobox 1; Somatostatin-transactivating factor 1; Pdx1
Background Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
Application Dilution
WB 1:300-1000
IHC-P 1:200-400
IF(ICC) 1:50-200