| Overview |
| bs-10092R |
| PLAG1 Polyclonal Antibody |
| WB, ELISA |
| Mouse |
| Human, Rat, Dog, Cow, Pig, Horse, Rabbit |
| Specifications |
| Unconjugated |
| Rabbit |
| KLH conjugated synthetic peptide derived from human PLAG1 |
| 51-150/500 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 5324 |
| Q6DJT9 |
| Nucleus |
| PSA; SGPA; ZNF912; Zinc finger protein PLAG1; Pleiomorphic adenoma gene 1 protein; PLAG1 |
| Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. |
| Application Dilution |
| WB |
1:300-5000 |
| ELISA |
1:500-1000 |
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