| Overview |
| bs-10329r |
| phospho-HDAC5 (Ser498) Polyclonal Antibody |
| WB, IHC-P, IHC-F, IF, Flow-Cyt |
| Human, Mouse, Rat, Bovine |
| Specifications |
| Unconjugated |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human HDAC5 around the phosphorylation site of Ser498 |
| Ser498 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20C for 12 months. |
| Target |
| Nucleus |
| HDAC5Ser498; HDAC5S498; p-HDAC5Ser498; p-HDAC5S498; HD 5; HD5; HDAC 5; Histone deacetylase 5; KIAA0600; NY CO 9; Antigen NY CO 9; FLJ90614; HDAC5_HUMAN; Antigen NY-CO-9. |
| Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
| Application Dilution |
| WB |
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| IHC-P |
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| IHC-F |
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| IF |
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| Flow-Cyt |
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