| Overview |
| bs-11168R-Biotin |
| RASSF5 Polyclonal Antibody, Biotin Conjugated |
| ELISA, IHC-P, IHC-F |
| Human, Mouse, Rat, Dog, Cow, Pig |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human RASSF5 |
| 321-418/418 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 83593 |
| Q8WWW0 |
| Cytoplasm |
| RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3; Ras association domain-containing protein 5; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; RASSF5 |
| Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. |
| Application Dilution |
| ELISA |
1:500-1000 |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
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