TPOR Polyclonal Antibody, Biotin Conjugated

Applications

  • WB
  • ELISA
  • IHC-P

Reactivity

  • Human
  • Mouse

Predicted Reactivity

  • Rat
  • Rabbit
Overview
Catalog # bs-11311R-Biotin
Product Name TPOR Polyclonal Antibody, Biotin Conjugated
Applications WB, ELISA, IHC-P
Reactivity Human, Mouse
Predicted Reactivity Rat, Rabbit
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human TPOR
Immunogen Range 401-500/635
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Subcellular location Cell membrane
Synonyms C MPL; C-MPL; CMPL; CD110; CD 110; MPL; MPLV; Myeloprolerative leukemia protein; Myeloprolerative leukemia virus oncogene; Proto-oncogene c-Mpl; THCYT2; Thrombopoietin receptor; TPO R; TPO-R; TPOR; TPOR_HUMAN.
Background Thrombopoietin (TPO or THPO), also known as c-Mpl ligand (c-Mpl L), is a cytokine that plays a central role in megakaryopoiesis by influencing the development and maturation of megakaryocytes and platelet production from hematopoietic stem cells. TPO exerts its biological effects through the TPO receptor, c-Mpl. c-Mpl is a member of the cytokine receptor superfamily. Expression of c-Mpl is restricted to hematopoietic tissues and cells, such as bone marrow, spleen, fetal liver and CD34+ cells. Stimulation of c-Mpl with TPO results in the activation of the Janus tyrosine kinase family members, Tyk 2 and JAK2, which in turn phosphorylate Stat5 and Stat3, causing their nuclear translocation and the transcription of Stat responsive genes. Muta-tions in c-Mpl have been implicated as the cause of certain human disorders, including congenital amegakaryocytic thrombocytopenia (CAMT) and thrombocytopenia with absent radii (TAR) syndrome.
Application Dilution
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400