Utrophin Polyclonal Antibody, APC-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-11394R-APC-Cy7 |
| Product Name | Utrophin Polyclonal Antibody, APC-Cy7 Conjugated |
| Applications |
FCM
|
| Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Dog, Cow, Sheep, Pig, Chicken |
| Specifications | |
| Conjugation | APC-Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human Utrophin |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 7402 |
| Synonyms | DMDL; DRP 1; DRP; DRP-1; DRP1; Dystrophin like protein; Dystrophin related protein 1; Dystrophin related protein; Dystrophin-related protein 1; FLJ23678; UTRN; UTRO_HUMAN; Utrophin homologous to dystrophin; Utrophin |
| Background | Dystrophin and utrophin are related structural, Actin-binding proteins that are involved in anchoring the cytoskeleton to the plasma membrane. Dystrophin is the protein product of the Duchenne/Becker muscular dystrophy gene. Dystrophin expression is found in muscle and brain tissues, where it is localized to the inner surface of the plasma membrane. It has been speculated that alternative splicing of the carboxy terminus allows dystrophin to interact with a variety of proteins. Research has shown that the loss of dystrophin-associated proteins in Duchenne afflicted muscle is due to the absence of dystrophin rather than to muscle degradation and that the lack of dystrophin results in the loss of linkage between the cytoskeleton and the extracellular matrix. Evidence suggests that the upregulation of utrophin can reduce the dystrophic pathology. |
| Application Dilution | |
| FCM | 1:100 |
Frequently asked questions
Which applications is Utrophin Polyclonal Antibody, APC-Cy7 Conjugated (bs-11394R-APC-Cy7) validated for, and at what dilution?
bs-11394R-APC-Cy7 is validated for FCM (1:100). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does Utrophin Polyclonal Antibody, APC-Cy7 Conjugated (bs-11394R-APC-Cy7) react with?
Tested reactivity: Human. Predicted reactivity (expected from sequence homology but not yet tested): Mouse, Rat, Dog, Cow, Sheep, Pig, Chicken.
How should bs-11394R-APC-Cy7 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise Utrophin Polyclonal Antibody, APC-Cy7 Conjugated (bs-11394R-APC-Cy7)?
KLH conjugated synthetic peptide derived from human Utrophin
What are the excitation and emission wavelengths of the APC-Cy7 conjugate (bs-11394R-APC-Cy7)?
APC-Cy7 on bs-11394R-APC-Cy7: excitation / emission 650nmn/780nm.