| Overview |
| bs-11501r-bf350-100ul |
| GFRA3/GDNF Receptor alpha 3 Antibody, AbBy Fluor-350 Conjugated |
| WB |
| Human, Mouse, Rat |
| Specifications |
| AbBy Fluor-350 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human GFR alpha 3 |
| 101-185/400 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| Cell membrane |
| GDNF family receptor alpha 3; GFR alpha 3; GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3; GFRA3; GFRA3_HUMAN; Glial cell line derived neurotrophic factor receptor alpha 3; GPI linked receptor. |
| Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF Beta superfamily of growth factors. Three receptors for these factors, GFR Alpha-1 (also designated GDNFR-Alpha, RETL1 or TrnR-1), GFR Alpha-2 (also designated GDNFR-Beta, RETL2, NTNR-Alpha or TrnR-2) and GFR Alpha-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFR Alpha-1 and GFR Alpha-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR Alpha-3 is expressed only during development. |
| Application Dilution |
| WB |
1:300-5000 |
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