| Overview |
| bs-11611r-pbs-only-100ul |
| p35/CDK5P1 Polyclonal Antibody, PBS Only Conjugated |
| WB, IHC-P, IF(IHC-P) |
| Human, Mouse, Rat |
| Specifications |
| PBS Only |
| Rabbit |
| KLH conjugated synthetic peptide derived from human p35 |
| 225-270/307 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| PBS (pH=7.4) |
| Store at 4°C for 12 months. |
| Target |
| 8851 |
| Q15078 |
| p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a; Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; CDK5R1 |
| p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
| IF(IHC-P) |
1:50-200 |
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