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    N-cadherin Polyclonal Antibody

    Description:
    Applications:
    • WB
    • IHC-P
    • IF(IHC-P)
    Overview
    Catalog # bs-1172R
    Product Name N-cadherin Polyclonal Antibody
    Applications WB, IHC-P, IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation Unconjugated
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human N-cadherin
    Immunogen Range 746-790/906
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Target
    Gene ID 1000
    Swiss Prot P19022
    Subcellular location Cytoplasm
    Synonyms CDHN; NCAD; CD325; CDw325; Cadherin-2; Neural cadherin; N-cadherin; CDH2
    Background Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).
    Applications
    Application Dilution
    WB 1:300-1000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200