alpha + beta Synuclein Antibody, Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-11787r-cy7-100uL |
| Product Name | alpha + beta Synuclein Antibody, Cy7 Conjugated |
| Applications |
IF(IHC-P)
IF(IHC-F)
IF(ICC)
|
| Reactivity | Human, Mouse, Rat, Zebrafish |
| Predicted Reactivity | Dog, Cow, Pig, Chicken, Rabbit |
| Specifications | |
| Conjugation | Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human alpha + beta Synuclein |
| Immunogen Range | 32-44/140 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Subcellular location | Cytoplasm, Cell membrane |
| Synonyms | Alpha synuclein; Beta synuclein; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; PARK1; PARK4; Parkinson disease familial 1; PD1; SNCA; SYUA_HUMAN; SNCB; SNCB protein; Synuclein alpha; Synuclein beta; SYUB_HUMAN. |
| Background | Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson?s disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson?s disease, Alzheimer?s disease and several other neurodegenerative illnesses. |
| Application Dilution | |
| IF(IHC-P) | 1:50-200 |
| IF(IHC-F) | 1:50-200 |
| IF(ICC) | 1:50-200 |
Frequently asked questions
Which applications is alpha + beta Synuclein Antibody, Cy7 Conjugated (bs-11787R-Cy7) validated for, and at what dilution?
bs-11787R-Cy7 is validated for IF(IHC-P) (1:50-200); IF(IHC-F) (1:50-200); IF(ICC) (1:50-200). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does alpha + beta Synuclein Antibody, Cy7 Conjugated (bs-11787R-Cy7) react with?
Tested reactivity: Human, Mouse, Rat, Zebrafish. Predicted reactivity (expected from sequence homology but not yet tested): Dog, Cow, Pig, Chicken, Rabbit.
How should bs-11787R-Cy7 be stored?
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise alpha + beta Synuclein Antibody, Cy7 Conjugated (bs-11787R-Cy7)?
KLH conjugated synthetic peptide derived from human alpha + beta Synuclein Immunogen range: 32-44/140.
What are the excitation and emission wavelengths of the Cy7 conjugate (bs-11787R-Cy7)?
Cy7 on bs-11787R-Cy7: excitation / emission 743nm/767nm.