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KALRN/Duo Polyclonal Antibody, Cy3 Conjugated


  • IF(IHC-P)
  • IF(IHC-F)
  • IF(ICC)

Predicted Reactivity

  • Human
  • Mouse
  • Rat
  • Dog
  • Pig
  • Horse
  • Chicken
Catalog # bs-11861R-Cy3
Product Name KALRN/Duo Polyclonal Antibody, Cy3 Conjugated
Applications IF(IHC-P), IF(IHC-F), IF(ICC)
Predicted Reactivity Human, Mouse, Rat, Dog, Pig, Horse, Chicken
Conjugation Cy3
Host Rabbit
Source KLH conjugated synthetic peptide derived from human KALRN/Duo
Immunogen Range 1401-1500/2985
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Subcellular location Cytoplasm
Synonyms Duo; FLJ16443; HAPIP; Huntingtin associated protein interacting protein duo ; Huntingtin-associated protein-interacting protein; Kalirin isoform 2; Kalirin; KALRN ; KALRN_HUMAN ; Protein Duo; RhoGEF kinase; Serine/threonine kinase with Dbl and pleckstrin homology domains ; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRAD.
Background HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington?s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
Application Dilution
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200