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    NPAS3 Polyclonal Antibody

    Overview
    Catalog # bs-11905R
    Product Name NPAS3 Polyclonal Antibody
    Applications WB, IHC-P, IF(IHC-P)
    Reactivity Human, Mouse, Rat
    Specifications
    Conjugation Unconjugated
    Host Rabbit
    Source KLH conjugated synthetic peptide derived from human NPAS3
    Clonality Polyclonal
    Isotype IgG
    Concentration 1ug/ul
    Purification Purified by Protein A.
    Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
    Target
    Synonyms Basic helix loop helix PAS protein MOP6; Basic-helix-loop-helix-PAS protein MOP6; bHLHe12; Class E basic helix-loop-helix protein 12; FLJ10003; FLJ11138; FLJ11605; Member of PAS protein 6; MOP 6; MOP6; Neuronal PAS domain containing protein 3; Neuronal PAS domain protein 3; Neuronal PAS domain-containing protein 3; Neuronal PAS3; NPAS 3; NPAS3; NPAS3_HUMAN; PAS domain-containing protein 6; PASD 6; PASD6.
    Background The Per-Arnt-Sim (PAS) domain is a 270 amino acid motif that mediates associations among various PAS family transcription factors. The PAS family contains neuronal specific transcription factors known as NPAS1, NPAS2 and NPAS3, which are involved the development and maintenance of learning and memory pathways. NPAS1 regulates erythropoietin expression in developing brain. NPAS2, also designated PAS 4/MOP4, associates with MOP3 to activate transcription. NPAS3, which localizes to the nucleus and is ubiquitously expressed in the adult brain, may be involved in neurogenesis and may control regulatory pathways relevant to psychotic illness and to schizophrenia. It regulates tracheal cell fates in the embryo and is necessary for the development of the posterior spiracles and the salivary gland duct. NPAS3 contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. Efficient DNA binding by NPAS2 requires dimerization with another bHLH protein.