CACNA1G + CACNA1H Polyclonal Antibody, AbBy Fluor-488 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-11984R-BF488 |
| Product Name | CACNA1G + CACNA1H Polyclonal Antibody, AbBy Fluor-488 Conjugated |
| Applications |
IF(IHC-P)
IF(IHC-F)
IF(ICC)
|
| Reactivity | Human, Mouse, Rat |
| Predicted Reactivity | Dog, Cow |
| Specifications | |
| Conjugation | AbBy Fluor-488 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from CACNA1G + CACNA1H |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Subcellular location | Cell membrane |
| Synonyms | Cav3.1c; Low voltage activated calcium channel alpha1 3.2 subunit; NBR13; Voltage dependent T type calcium channel subunit alpha 1G; Voltage dependent T type calcium channel subunit alpha 1H; Voltage gated calcium channel subunit alpha Cav3.1; Voltage gated calcium channel subunit alpha Cav3.2; CAC1G_HUMAN; CAC1H_HUMAN. |
| Background | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing. |
| Application Dilution | |
| IF(IHC-P) | 1:50-200 |
| IF(IHC-F) | 1:50-200 |
| IF(ICC) | 1:50-200 |
Frequently asked questions
Which applications is CACNA1G + CACNA1H Polyclonal Antibody, AbBy Fluor-488 Conjugated (bs-11984R-BF488) validated for, and at what dilution?
bs-11984R-BF488 is validated for IF(IHC-P) (1:50-200); IF(IHC-F) (1:50-200); IF(ICC) (1:50-200). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does CACNA1G + CACNA1H Polyclonal Antibody, AbBy Fluor-488 Conjugated (bs-11984R-BF488) react with?
Tested reactivity: Human, Mouse, Rat. Predicted reactivity (expected from sequence homology but not yet tested): Dog, Cow.
How should bs-11984R-BF488 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise CACNA1G + CACNA1H Polyclonal Antibody, AbBy Fluor-488 Conjugated (bs-11984R-BF488)?
KLH conjugated synthetic peptide derived from CACNA1G + CACNA1H
What are the excitation and emission wavelengths of the AbBy Fluor-488 conjugate (bs-11984R-BF488)?
AbBy Fluor-488 on bs-11984R-BF488: excitation / emission 499nm/519nm.