KAT3A / CBP Polyclonal Antibody, AbBy Fluor-488 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-12395R-BF488 |
| Product Name | KAT3A / CBP Polyclonal Antibody, AbBy Fluor-488 Conjugated |
| Applications |
IF
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | AbBy Fluor-488 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human KAT3A/CBP |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 1387 |
| Synonyms | CBP; CBP/p300; CBP_HUMAN; CREB binding protein; CREB-binding protein; CREBBP; Cyclic AMP responsive enhancer binding protein; Cyclic AMP-responsive enhancer binding protein; KAT3A; RSTS; RTS; Rubinstein Taybi syndrome; Rubinstein-Taybi syndrome. |
| Background | Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression, even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators. |
| Application Dilution | |
| IF | |
Frequently asked questions
Which applications is KAT3A / CBP Polyclonal Antibody, AbBy Fluor-488 Conjugated (bs-12395R-BF488) validated for, and at what dilution?
bs-12395R-BF488 is validated for IF.
Which species does KAT3A / CBP Polyclonal Antibody, AbBy Fluor-488 Conjugated (bs-12395R-BF488) react with?
Tested reactivity: Human, Mouse, Rat.
How should bs-12395R-BF488 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise KAT3A / CBP Polyclonal Antibody, AbBy Fluor-488 Conjugated (bs-12395R-BF488)?
KLH conjugated synthetic peptide derived from human KAT3A/CBP