human Fibrinogen Polyclonal Antibody

Applications

  • ELISA

Reactivity

  • Human
Overview
Catalog # bs-1240R
Product Name human Fibrinogen Polyclonal Antibody
Applications ELISA
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Fibrinogen from human plasma
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Target
Gene ID 2243
Swiss Prot P02671
Synonyms Fib2; Fibrinogen alpha chain; FGA
Background Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Application Dilution
ELISA 1:500-1000