CYP1B1 Polyclonal Antibody, AbBy Fluor-594 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-12926R-BF594 |
| Product Name | CYP1B1 Polyclonal Antibody, AbBy Fluor-594 Conjugated |
| Applications |
WB
|
| Reactivity | Mouse |
| Predicted Reactivity | Human, Rat, Dog, Horse |
| Specifications | |
| Conjugation | AbBy Fluor-594 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human CYP1B1 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 1545 |
| Swiss Prot | Q16678 |
| Subcellular location | Cytoplasm, Cell membrane |
| Synonyms | CP1B; GLC3A; CYPIB1; P4501B1; Cytochrome P450 1B1; CYP1B1 |
| Background | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression. |
| Application Dilution | |
| WB | 1:300-5000 |
Frequently asked questions
Which applications is CYP1B1 Polyclonal Antibody, AbBy Fluor-594 Conjugated (bs-12926R-BF594) validated for, and at what dilution?
bs-12926R-BF594 is validated for WB (1:300-5000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does CYP1B1 Polyclonal Antibody, AbBy Fluor-594 Conjugated (bs-12926R-BF594) react with?
Tested reactivity: Mouse. Predicted reactivity (expected from sequence homology but not yet tested): Human, Rat, Dog, Horse.
How should bs-12926R-BF594 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise CYP1B1 Polyclonal Antibody, AbBy Fluor-594 Conjugated (bs-12926R-BF594)?
KLH conjugated synthetic peptide derived from human CYP1B1
What are the excitation and emission wavelengths of the AbBy Fluor-594 conjugate (bs-12926R-BF594)?
AbBy Fluor-594 on bs-12926R-BF594: excitation / emission 590nm/617nm.