ESAT6 Polyclonal Antibody

Applications

  • IHC-P
  • IF(IHC-P)

Reactivity

  • Bacteria
Overview
Catalog # bs-13107R
Product Name ESAT6 Polyclonal Antibody
Applications IHC-P, IF(IHC-P)
Reactivity Bacteria
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic peptide derived from Mycobacterium tuberculosis ESAT6
Immunogen Range 10-50/95
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Target
Subcellular location Secreted
Synonyms 6 kDa early secretory antigenic target; 6 kDa early secretory antigenic target ESXA; ESAT 6; esaT6; ESXA; ESXA_MYCTU.
Background Mycobacterium tuberculosis is a slow-growing obligate aerobic bacillus that causes most cases of tuberculosis (TB). It is a small, rod-like microbe that can withstand weak disinfectants and survive in a dry state for weeks, but can only grow within a host organism. M. tuberculosis has a thick waxy cell wall that is responsible for the typical caseous granuloma formation in tuberculosis. ESAT6 is a protein secreted by M. tuberculosis that induces a strong immune response in infected organisms, making it a strong candidate for the development of a vaccine against tuberculosis. ESAT6 may also be useful in the detection of the disease. Deletion of the ESAT6 gene leads to the loss of virulence of M. tuberculosis.
Application Dilution
IHC-P 1:200-400
IF(IHC-P) 1:50-200