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phospho-Dnmt3a (Ser390 + Ser393) Polyclonal Antibody, Cy5.5 Conjugated

Applications

  • WB

Reactivity

  • Human
Overview
Catalog # bs-14399R-Cy5.5
Product Name phospho-Dnmt3a (Ser390 + Ser393) Polyclonal Antibody, Cy5.5 Conjugated
Applications WB
Reactivity Human
Specifications
Conjugation Cy5.5
Host Rabbit
Source KLH conjugated Synthesised phosphopeptide derived from human Dnmt3a around the phosphorylation site of Ser390 + Ser393
Modification Site Ser390 + Ser393
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 1788
Swiss Prot Q9Y6K1
Subcellular location Cytoplasm, Nucleus
Synonyms Dnmt3a (phospho S390 + S393); Dnmt3a (phospho Ser390 + Ser393); p-Dnmt3a (phospho S390 + S393); DNA (cytosine 5) methyltransferase 3 alpha; DNA (cytosine 5) methyltransferase 3A; DNA (cytosine-5)-methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNM3A_HUMAN; DNMT 3a; DNMT; Dnmt3a; DNMT3A2; M.HsaIIIA; MCMT; OTTHUMP00000201149.
Background Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.
Application Dilution
WB 1:300-5000