phospho-KSR1 (Ser404) Polyclonal Antibody

Overview
Catalog #	bs-16868r
Product Name	phospho-KSR1 (Ser404) Polyclonal Antibody
Applications	WB
Reactivity	Human
Predicted Reactivity	Mouse, Rat, Dog, Pig
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthesised phosphopeptide derived from human KSR1 around the phosphorylation site of Ser404
Modification Site	Ser404
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	8844
Swiss Prot	Q8IVT5
Subcellular location	Cytoplasm, Cell membrane
Synonyms	KSR1 (phospho S404); p-KSR1 (phospho S404); BKSR 1; BKSR1; dKsr; EK 31; EK31; hb; Kinase suppressor of Ras 1; Kinase suppressor of ras; KSR 1; KSR; KSR1; KSR1_HUMAN; Positive Ras signaling mediator family member (86.4 kD); Positive Ras signaling mediator family member; RSU 2; RSU2; SR 31; SR31; Suppressor of activated let 60 Ras SUR3; Suppressor of Ras1 31.
Background	KSR1 is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. It was initially considered to be a protein kinase acting in the Ras pathway. KSR1 is required for maximal ERK activation induced by growth factors and by some cytotoxic agents. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane associated.
Application Dilution
WB