phospho-TrkA (Tyr490) Polyclonal Antibody, HRP Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-17445R-HRP-100uL |
| Product Name | phospho-TrkA (Tyr490) Polyclonal Antibody, HRP Conjugated |
| Applications |
WB
IHC-P
IHC-F
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | HRP |
| Host | Rabbit |
| Source | KLH conjugated synthesised phosphopeptide derived from human TrkA isoform 1(790aa) around the phosphorylation site of Tyr490 |
| Modification Site | Tyr490 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 4914 |
| Swiss Prot | P04629 |
| Synonyms | TrkA (phospho Y490); TrkA (phospho Tyr790); p-TrkA (phospho Y490); NTRK1(phospho Y490); CIPA; High affinity nerve growth factor receptor precursor; MTC; Neurotrophic tyrosine kinase receptor type 1; Ntrk 1; Ntrk1; Oncogene TRK; p140 TrkA; TRK 1; Trk A; TRK; TRK1; TRK1 transforming tyrosine kinase protein; Tyrosine Receptor Kinase A. |
| Background | The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor , gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex. |
| Application Dilution | |
| WB | |
| IHC-P | |
| IHC-F | |
Frequently asked questions
Which applications is phospho-TrkA (Tyr490) Polyclonal Antibody, HRP Conjugated (bs-17445R-HRP) validated for, and at what dilution?
bs-17445R-HRP is validated for WB.
Which species does phospho-TrkA (Tyr490) Polyclonal Antibody, HRP Conjugated (bs-17445R-HRP) react with?
Tested reactivity: Human, Mouse, Rat.
How should bs-17445R-HRP be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise phospho-TrkA (Tyr490) Polyclonal Antibody, HRP Conjugated (bs-17445R-HRP)?
KLH conjugated synthesised phosphopeptide derived from human TrkA isoform 1(790aa) around the phosphorylation site of Tyr490