| Overview |
| bs-1990R-PE |
| MITF Polyclonal Antibody, PE Conjugated |
| WB |
| Mouse, Others |
| Human, Rat, Dog, Cow, Horse, Chicken, Rabbit |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human MITF |
| 351-450/526 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 4286 |
| O75030 |
| Nucleus |
| MI; WS2; CMM8; WS2A; bHLHe32; Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; MITF |
| Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. |
| Application Dilution |
| WB |
1:300-5000 |
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