Neutrophil Elastase Polyclonal Antibody, PerCP-Cy5.5 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-23549R-PerCP-Cy5.5 |
Product Name | Neutrophil Elastase Polyclonal Antibody, PerCP-Cy5.5 Conjugated |
Applications | IF(IHC-P), IF(IHC-F), IF(ICC) |
Reactivity | Mouse |
Predicted Reactivity | Dog |
Specifications | |
Conjugation | PerCP-Cy5.5 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human Neutrophil Elastase |
Immunogen Range | 51-150/265 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Affinity purified by Protein A |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Swiss Prot | Q3UP87 |
Synonyms | Bone Marrow Serine Protease; ELA 2; ELA2; ELANE; Elastase 2; Elastase-2; Elastase 2 neutrophil; Leukocyte Elastase Precursor; Medullasin; NE; Neutrophil elastase; Neutrophill elastase; PMN E; PMN Elastase; Polymorphonuclear elastase; SCN1; Serine protease; SERP1. |
Background | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]. |
Application Dilution | |
IF(IHC-P) | 1:100-500 |
IF(IHC-F) | 1:100-500 |
IF(ICC) | 1:100-500 |