KIR3DL1 Polyclonal Antibody, AbBy Fluor-350 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-2421R-BF350-100uL |
| Product Name | KIR3DL1 Polyclonal Antibody, AbBy Fluor-350 Conjugated |
| Applications |
WB
|
| Reactivity | Human |
| Predicted Reactivity | Mouse, Rat |
| Specifications | |
| Conjugation | AbBy Fluor-350 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from mouse CD158e |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Swiss Prot | P83555 |
| Subcellular location | Cell membrane |
| Synonyms | KIR3DL1; Killer cell immunoglobulin-like receptor 3DL1; AMB11; CD158 antigen-like family member E; CD158E; CD158e antigen; CD158E1; CD158E1/2; CD158E2; CL11; CL2; HLA-BW4-specic inhibitory NK cell receptor; killer cell immunoglobulin like receptor; Killer cell immunoglobulin like receptor three domains , short cytoplasmic tail, 1; Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1; KIR; KIR antigen 3DL1; KIR G1; KIR3DS1; Kirl1; Kirl2; Krl1; MGC119726; MGC119728; MGC126589; MGC126591; MHC class I NK cell receptor; Natural killer associated transcript 3; Natural killer cell inhibitory receptor; NK receptor; NK-associated transcript 10; NK-associated transcript 3; NK-associated transcript 3delIg1; NKAT10; NKAT3; NKB1; NKB1B; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL 2/CL 11; KI3L1_MOUSE. |
| Background | KIR3DL1 (NKB1, CD158e1) is expressed on a subset of natural killer cells and T cells. NKB1 is a 70 kD member of the immunoglobulin superfamily that is expressed at varying levels among individuals. NKB1 is a type I membrane protein containing two immunoglobulin C2 type domains. The interaction of NKB1 with specific HLA B antigens on a target cell (the HLA Bw4 allele, for example) inhibits cytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to be important in NK and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower the threshold for activation through activating receptors and increase inflammation and susceptibility to autoimmune disease. |
| Application Dilution | |
| WB | 1:300-5000 |
Frequently asked questions
Which applications is KIR3DL1 Polyclonal Antibody, AbBy Fluor-350 Conjugated (bs-2421R-BF350) validated for, and at what dilution?
bs-2421R-BF350 is validated for WB (1:300-5000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does KIR3DL1 Polyclonal Antibody, AbBy Fluor-350 Conjugated (bs-2421R-BF350) react with?
Tested reactivity: Human. Predicted reactivity (expected from sequence homology but not yet tested): Mouse, Rat.
How should bs-2421R-BF350 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise KIR3DL1 Polyclonal Antibody, AbBy Fluor-350 Conjugated (bs-2421R-BF350)?
KLH conjugated synthetic peptide derived from mouse CD158e
What are the excitation and emission wavelengths of the AbBy Fluor-350 conjugate (bs-2421R-BF350)?
AbBy Fluor-350 on bs-2421R-BF350: excitation / emission 346nm/442nm.