KiSS1 receptor Polyclonal Antibody, AbBy Fluor-405 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-2501R-BF405 |
| Product Name | KiSS1 receptor Polyclonal Antibody, AbBy Fluor-405 Conjugated |
| Applications |
WB
|
| Reactivity | Human, Mouse, Rat |
| Predicted Reactivity | Dog, Sheep, Pig, GuineaPig |
| Specifications | |
| Conjugation | AbBy Fluor-405 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human KiSS1 receptor |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 84634 |
| Swiss Prot | Q969F8 |
| Subcellular location | Cell membrane |
| Synonyms | HH8; CPPB1; GPR54; AXOR12; KISS-1R; HOT7T175; KiSS-1 receptor; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; Hypogonadotropin-1; Kisspeptins receptor; Metastin receptor; KISS1R |
| Background | Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
| Application Dilution | |
| WB | 1:300-5000 |
Frequently asked questions
Which applications is KiSS1 receptor Polyclonal Antibody, AbBy Fluor-405 Conjugated (bs-2501R-BF405) validated for, and at what dilution?
bs-2501R-BF405 is validated for WB (1:300-5000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does KiSS1 receptor Polyclonal Antibody, AbBy Fluor-405 Conjugated (bs-2501R-BF405) react with?
Tested reactivity: Human, Mouse, Rat. Predicted reactivity (expected from sequence homology but not yet tested): Dog, Sheep, Pig, GuineaPig.
How should bs-2501R-BF405 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise KiSS1 receptor Polyclonal Antibody, AbBy Fluor-405 Conjugated (bs-2501R-BF405)?
KLH conjugated synthetic peptide derived from human KiSS1 receptor
What are the excitation and emission wavelengths of the AbBy Fluor-405 conjugate (bs-2501R-BF405)?
AbBy Fluor-405 on bs-2501R-BF405: excitation / emission 401nm/421nm.