SLAMF7/CD319/CS1 Polyclonal Antibody, Biotin Conjugated

Applications

  • WB
  • ELISA

Reactivity

  • Human
  • Mouse

Predicted Reactivity

  • Rat
  • Cow
Overview
Catalog # bs-2544R-Biotin
Product Name SLAMF7/CD319/CS1 Polyclonal Antibody, Biotin Conjugated
Applications WB, ELISA
Reactivity Human, Mouse
Predicted Reactivity Rat, Cow
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human SLAMF7
Immunogen Range 51-160/335
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Swiss Prot Q9NQ25
Subcellular location Cell membrane
Synonyms 19A; 19A24 protein; CD 319; CD2 like receptor activating cytotoxic cells; CD2 subset 1; CD319; CD319 antigen; CRACC; CS1; Membrane protein FOAP 12; Novel Ly9; Novel LY9 lymphocyte antigen 9 like protein; Protein 19A; SLAM family member 7; SLAMF 7.
Background SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
Application Dilution
WB 1:300-5000
ELISA 1:500-1000