DEP1/PTPRJ Polyclonal Antibody, AbBy Fluor-594 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-2567r-bf594 |
| Product Name | DEP1/PTPRJ Polyclonal Antibody, AbBy Fluor-594 Conjugated |
| Applications |
WB
|
| Reactivity | Human, Mouse |
| Predicted Reactivity | Rat, Rabbit |
| Specifications | |
| Conjugation | AbBy Fluor-594 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human PTPRJ |
| Immunogen Range | 865-970/1337 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 5795 |
| Swiss Prot | Q12913 |
| Subcellular location | Cell membrane |
| Synonyms | DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA; Receptor-type tyrosine-protein phosphatase eta; Protein-tyrosine phosphatase eta; Density-enhanced phosphatase 1; DEP-1; HPTP eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; PTPRJ |
| Background | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. |
| Application Dilution | |
| WB | 1:300-5000 |
Frequently asked questions
Which applications is DEP1/PTPRJ Polyclonal Antibody, AbBy Fluor-594 Conjugated (bs-2567R-BF594) validated for, and at what dilution?
bs-2567R-BF594 is validated for WB (1:300-5000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does DEP1/PTPRJ Polyclonal Antibody, AbBy Fluor-594 Conjugated (bs-2567R-BF594) react with?
Tested reactivity: Human, Mouse. Predicted reactivity (expected from sequence homology but not yet tested): Rat, Rabbit.
How should bs-2567R-BF594 be stored?
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise DEP1/PTPRJ Polyclonal Antibody, AbBy Fluor-594 Conjugated (bs-2567R-BF594)?
KLH conjugated synthetic peptide derived from human PTPRJ Immunogen range: 865-970/1337.
What are the excitation and emission wavelengths of the AbBy Fluor-594 conjugate (bs-2567R-BF594)?
AbBy Fluor-594 on bs-2567R-BF594: excitation / emission 590nm/617nm.