| Overview |
| bs-2686R-PE |
| DKK3 Polyclonal Antibody, PE Conjugated |
| WB |
| Mouse, Rabbit |
| Human, Rat, Cow, Pig, Horse |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human DKK3 |
| 31-130/350 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 27122 |
| Q9UBP4 |
| Secreted |
| RIG; REIC; Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3; DKK3; UNQ258/PRO295 |
| Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). |
| Application Dilution |
| WB |
1:300-5000 |
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