CITED1 Polyclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bs-2990R-100uL |
| Product Name | CITED1 Polyclonal Antibody |
| Applications |
WB
|
| Reactivity | Human, Mouse |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human CITED1 |
| Immunogen Range | 121-193/193 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | Lot Dependent |
| Purification | purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 4435 |
| Swiss Prot | Q99966 |
| Subcellular location | Cytoplasm, Nucleus |
| Synonyms | MSG1; Cbp/p300-interacting transactivator 1; Melanocyte-specific protein 1; CITED1 |
| Background | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. |
| Application Dilution | |
| WB | 1:300-5000 |
Frequently asked questions
Which applications is CITED1 Polyclonal Antibody (bs-2990R) validated for, and at what dilution?
bs-2990R is validated for WB (1:300-5000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does CITED1 Polyclonal Antibody (bs-2990R) react with?
Tested reactivity: Human, Mouse.
How should bs-2990R be stored?
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise CITED1 Polyclonal Antibody (bs-2990R)?
KLH conjugated synthetic peptide derived from human CITED1 Immunogen range: 121-193/193.