MSH6 Polyclonal Antibody, Biotin Conjugated

ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.", "Category"=>"Conjugated Primary Antibody", "Clonality"=>"Polyclonal", "Concentration"=>"1ug/ul", "Conjugation"=>"Biotin", "Cross Reactive Species"=>"Human, Rat", "Datasheet URL"=>"https://www.biossusa.com/store/datasheets/bs-3804R-Biotin", "Excitation Emission"=>"N/A", "Gene ID"=>"2956", "Gene ID Link"=>"Entrez Gene: 2956", "Host"=>"Rabbit", "Immunogen Sequence"=>"812-910/1360", "Isotype"=>"IgG", "Lead Time"=>"10 to 15 business days.", "Modification"=>"Unmodified", "Predicted Reactivity"=>"Mouse, Dog, Cow, Sheep, Pig, Rabbit", "Product URL"=>"https://www.biossusa.com/products/bs-3804R-Biotin", "Purification"=>"Purified by Protein A.", "Size"=>"100ul", "Source"=>"KLH conjugated synthetic peptide derived from human MSH6", "Storage"=>"Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20°C for 12 months.", "Storage Buffer"=>"Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.", "Storage Condition"=>"Store at -20°C for 12 months.", "Subcellular Locations"=>"Nucleus", "Swiss Prot"=>"P52701", "Swiss Prot Link"=>"Swiss Prot: P52701", "Synonyms"=>"GTBP; HSAP; p160; GTMBP; HNPCC5; DNA mismatch repair protein Msh6; hMSH6; G/T mismatch-binding protein; MutS-alpha 160 kDa subunit; MSH6", "Target Protein"=>"MSH6"} -->