Overview |
bs-3814R-HRP |
Ube1L/UBE2 Polyclonal Antibody, HRP Conjugated |
IHC-P, IHC-F |
Human, Mouse, Rat, Cow, Pig, Horse, Rabbit |
Specifications |
HRP |
Rabbit |
KLH conjugated synthetic peptide derived from human Ube1L |
401-500/1012 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
7318 |
Cytoplasm, Nucleus |
D8; UBA7; Ube 1L; UBE 2; UBE2; Ubiquitin activating enzyme 2; Ubiquitin activating enzyme E1 homolog; Ubiquitin Activating Enzyme E1 Like; Ubiquitin activating enzyme E1 related protein; UBA7_HUMAN. |
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]. |
Application Dilution |
IHC-P |
1:200-400 |
IHC-F |
1:100-500 |