presenilin 2/PS-2 Polyclonal Antibody, APC-Cy7 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-3815R-APC-Cy7-100uL |
| Product Name | presenilin 2/PS-2 Polyclonal Antibody, APC-Cy7 Conjugated |
| Applications |
WB
IF(IHC-P)
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | APC-Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human presenilin 2/PS-2 |
| Immunogen Range | 51-150/448 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 5664 |
| Synonyms | AD 3L; AD 3LP; AD 4; AD 5; AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; Alzheimer disease familial type 4; E5 1; Presenilin2; Presenilin 2; Presenilin 2; PS 2; PS2; PSEN 2; PSNL 2; PSNL2; STM 2; STM2. |
| Background | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. |
| Application Dilution | |
| WB | 1:300-5000 |
| IF(IHC-P) | 1:50-200 |
Frequently asked questions
Which applications is presenilin 2/PS-2 Polyclonal Antibody, APC-Cy7 Conjugated (bs-3815R-APC-Cy7) validated for, and at what dilution?
bs-3815R-APC-Cy7 is validated for WB (1:300-5000); IF(IHC-P) (1:50-200). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does presenilin 2/PS-2 Polyclonal Antibody, APC-Cy7 Conjugated (bs-3815R-APC-Cy7) react with?
Tested reactivity: Human, Mouse, Rat.
How should bs-3815R-APC-Cy7 be stored?
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise presenilin 2/PS-2 Polyclonal Antibody, APC-Cy7 Conjugated (bs-3815R-APC-Cy7)?
KLH conjugated synthetic peptide derived from human presenilin 2/PS-2 Immunogen range: 51-150/448.
What are the excitation and emission wavelengths of the APC-Cy7 conjugate (bs-3815R-APC-Cy7)?
APC-Cy7 on bs-3815R-APC-Cy7: excitation / emission 650nm/780nm.