Legumain Polyclonal Antibody

Applications

  • WB
  • ELISA
  • FCM
  • IHC-P

Reactivity

  • Human
  • Mouse
  • Rat

Predicted Reactivity

  • Dog
  • Cow
  • Horse
Overview
Catalog # bs-3907R
Product Name Legumain Polyclonal Antibody
Applications WB, ELISA, FCM, IHC-P
Reactivity Human, Mouse, Rat
Predicted Reactivity Dog, Cow, Horse
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic peptide derived from human Legumain
Immunogen Range 201-300/433
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Condition Store at -20°C for 12 months..
Target
Gene ID 5641
Swiss Prot Q99538
Subcellular location Cytoplasm
Synonyms AEP; LGMN1; PRSC1; Legumain; Asparaginyl endopeptidase; Protease, cysteine 1; LGMN
Background Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Application Dilution
WB 1:300-1000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400