| Overview |
| bs-3943R-Biotin |
| G protein beta 3/GNB3 Antibody, Biotin Conjugated |
| ELISA, IHC-P, IHC-F |
| Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human G protein beta 3 |
| 81-180/340 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 2784 |
| Cytoplasm, Cell membrane |
| Gnb3; Guanine nucleotide binding protein G protein, beta polypeptide 3; Guanine nucleotide binding protein G; Hypertension associated protein; IG; SG; Transducin beta chain 3; Tsubunit beta 3; GBB3_HUMAN. |
| G proteins are composed of 3 units, alpha, beta and gamma and are involved in the modulation and transduction of various transmembrane signalling systems. There are families of related genes for each subunit. GNB3 encodes a beta subunit. Beta subunits are required for GTPase activity, for replacement of GDP by GTP, regulate alpha subunits and for G protein-effector interactions. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity and is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. |
| Application Dilution |
| ELISA |
1:500-1000 |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
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